Week 16 of the NFL will close with this conference tilt in Indianapolis on Monday, December 26, so make sure you don’t miss out on the best Chargers vs. Colts betting pick and odds.

Los Angeles is searching for the third win in a row, while Indianapolis hopes to avoid the fifth consecutive defeat when they face at Lucas Oil Stadium. The Chargers are -4.5 favorites on Jazz Sportsbook, while the total is set at 46 points. These AFC rivals will meet for the first time since 2019.

Chargers edged the Titans at home

The Los Angeles Chargers (8-6-0, 8-5-1 ATS) bounced back from a loss to the divisional foes Las Vegas Raiders on the road with a pair of home victories over the Miami Dolphins and Tennessee Titans. The Chargers had a 14-7 lead against Tennessee entering the final minute of the game when the visitors tied, but when everyone thought the tilt is heading to overtime, the hosts got a 17-14 win thanks to Cameron Dicker’s 43-yeard field goal.

Justin Herbert completed 28 of 42 passes for 313 yards and two interceptions – it was only the second time this year he failed to throw for a TD. Austin Ekeler and Joshua Kelley scored a rushing touchdown apiece and combined for 82 yards on 22 carries. Keenan Allen led all the receivers with 86 yards on eight catches, while Mike Williams had 67 yards on four catches. Defensively, Drue Tranquill was solid with a game-high ten tackles and a sack.

K Dustin Hopkins (hamstring), DE Joey Bosa (groin), CB J.C. Jackson (knee), WR Jalen Guyton (knee), and RB Joshua Kelley (MCL) are out indefinitely. RB Austin Ekeler (shoulder) and S Derwin James Jr. (quad) are questionable to feature on Monday against the Colts.

Colts dropped a massive lead in a loss to the Vikings

The Indianapolis Colts (4-9-1, 6-8-0 ATS) had a massive 33-0 halftime lead against the Minnesota Vikings in Minneapolis but managed to drop it and lose 39-36 in overtime. The Colts wrote a negative record by becoming the first team that dropped a 33-point lead and lose, but given the stats, they didn’t deserve to win. Minnesota was better in total yards (518-341) and first downs (32-20), but Indianapolis did force three turnovers opposite the Vikings’ one.

Julian Blackmon turned one of those turnovers into a pick-six in the second quarter to give the Colts a 30-0 lead. Matt Ryan completed 19 of 33 passes for 182 yards and one touchdown. Deon Jackson caught that lone TD pass from Ryan, while Michael Pittman Jr. led Indy with 60 yards on ten receptions.

On the ground, Zack Moss had a team-high 85 yards on 24 carries, while Deon Jackson added 13 rushes for 55 yards. On defense, Indianapolis recorded seven sacks opposite Minnesota’s three. Dayo Odeyingbo had two of those sacks, while Bobby Okereke and Zaire Franklin combined for 22 tackles.

P Rigoberto Sanchez (Achilles), LB Shaquille Leonard (back), S Armani Watts (ankle), and RB Jonathan Taylor (ankle) are out for the season. CB Kenny Moore II 9shin) is questionable to face the Chargers on Monday.


Los Angeles:

  • 5-2 ATS in the last seven road games
  • 10-3-1 ATS in the last 14 games after accumulating less than 90 yards rushing in their previous game


  • 2-5 ATS in the last seven games following an ATS win
  • 2-8 ATS in the last ten games after allowing more than 250 yards passing in their previous game

Los Angeles Chargers vs. Indianapolis Colts Pick

Indianapolis will start Nick Foles instead of Matt Ryan under the center, and considering that Foles played one game in two years, I am giving an advantage to the Chargers here. Although the Colts have a solid pass defense that allows 205.6 yards per game, the Chargers have the second-best pass offense in the NFL that averages 274.2 ypg.

I am sure Herbert, Allen, Williams, and Palmer will combine for multiple touchdowns on Monday. Los Angeles’ defense is not good, especially when it comes to the running, but luckily for the visitors, the Colts’ run offense is 25th in the league.

Pick: Take the Chargers at -4.5 (-110)

The Total

I mentioned the Chargers’ weak defense, but they did keep the rivals to just 31 points in total in the last two games, which is quite promising for the team with playoff aspirations. If we put the most recent game aside, Indianapolis is struggling offensively and it’s going to be surprising if the hosts score more than 17 points here, especially with a new starting QB. That’s why I expect a low-scoring tilt. Under is 4-1-1 in the last six H2H meetings; Under is 5-2 in the Chargers’ previous seven games overall, while Under is 6-2 in the Colts’ last eight home games.

Pick: Go Under 47.5 points (-110)