The St. Louis Cardinals and Los Angeles Angels wrap up their interleague set on July 22, 2026, with Hunter Dobbins getting the ball against Reid Detmers in Anaheim. The Angels sit as a modest home favorite on the moneyline (Angels -126, Cardinals +108), with Los Angeles also priced on the -1.5 run line (+164) and an 8.5 total that’s shaded to the over (-122).
St. Louis Cardinals vs Los Angeles Angels Game Info
| Matchup | St. Louis Cardinals @ Los Angeles Angels |
| Date | July 22, 2026 |
| Time | 4:08 PM ET (1:08 PM PT) |
| Location | Angel Stadium (Anaheim, CA) |
| How to Watch | Cardinals.TV Presented by bet365, ABTV (presented by Pechanga Resort Casino) |
St. Louis Cardinals vs Los Angeles Angels Full Odds
| Market | St. Louis Cardinals | Los Angeles Angels |
|---|---|---|
| Moneyline | +108 | -126 |
| Run Line | +1.5 (-200) | -1.5 (+164) |
| Total (8.5) | Over 8.5 (-122) | Under 8.5 (+100) |
St. Louis Cardinals vs Los Angeles Angels Team Stats
| Team | Record | Runs Scored | Runs Allowed | Run Diff | Runs/Game | Runs Allowed/Game |
|---|---|---|---|---|---|---|
| St. Louis Cardinals | 51-49 | 447 | 448 | -1 | 4.47 | 4.48 |
| Los Angeles Angels | 41-61 | 442 | 499 | -57 | 4.33 | 4.89 |
St. Louis Cardinals vs Los Angeles Angels Starting Pitcher Stats
| Pitcher | Hand | 2026 W-L | ERA | IP | SO | WHIP |
|---|---|---|---|---|---|---|
| Hunter Dobbins (STL) | RHP | 1-1 | 4.03 | 22.1 | 23 | 1.39 |
| Reid Detmers (LAA) | LHP | 3-6 | 4.16 | 114.2 | 130 | 1.12 |
St. Louis Cardinals vs Los Angeles Angels Recent Form and Pitching Notes
St. Louis Cardinals (51-49) come in looking to avoid the sweep after a 5-1 loss on July 21. Matthew Liberatore was tagged early (5.1 IP, 5 ER, 7 SO) but steadied the game afterward, which limited the bullpen workload to just 2.2 innings. Offensively, St. Louis’ lone run came in the fifth, and the bigger issue was falling behind immediately and playing the rest of the night uphill.
Los Angeles Angels (41-61) secured the series on July 21 behind a five-run first inning and a clean pitching script. Walbert Ureña delivered six strong innings (6.0 IP, 1 ER, 5 SO), and the bullpen finished it off with three scoreless frames to close the door. The Angels did their damage early, highlighted by Jorge Soler’s two-run double and Jo Adell’s two-run homer, which is exactly the kind of front-loaded scoring that plays well at home when the bullpen can be kept in lanes.
For July 22, Dobbins brings a limited MLB sample (five appearances, three starts), and his recent game log shows a mix of swing-and-miss and traffic: he went 5.0 innings with 3 earned runs and 3 walks in his most recent outing (July 7 vs. Milwaukee), but also has a 5.0-inning, scoreless effort in early June. Detmers has the more established profile and has been sharper of late, coming off a strong start on July 17 vs. Detroit (6.0 IP, 0 ER, 7 SO), a reminder of how he can control a game when his fastball/slider combo is landing early in counts.
St. Louis Cardinals vs Los Angeles Angels Betting Trends
- St. Louis Cardinals: Game total has gone Under in 30 of their last 50 games
- Los Angeles Angels: Game total has gone Under in 28 of their last 45 home games
- St. Louis Cardinals: Team total has gone Over in 30 of their last 45 away games
- Los Angeles Angels: Team total has gone Under in 14 of their last 20 games
- St. Louis Cardinals: Have covered the run line in 27 of their last 45 away games
- Los Angeles Angels: Have won the 1st five innings moneyline in 27 of their last 50 home games
St. Louis Cardinals vs Los Angeles Angels Breakdown
This matchup is priced like a coin flip with a home lean, and it makes sense: the Cardinals have been the steadier team over the full season, but the Angels get the more bankable starter on paper with Detmers. If Detmers looks like he did in his last start pounding the zone, getting to two strikes, and finishing hitters Los Angeles can keep St. Louis from getting into the middle of the bullpen early, which matters with a total sitting at 8.5.
The key tension point is on the other side: Dobbins’ inexperience at the MLB level is less about talent and more about sequence. The Angels just showed they’re willing to attack early in counts and turn a game into a bullpen-management advantage by the second inning. If Dobbins can get through the top of the order clean the first time, St. Louis’ overall balance gives them a real path to flipping this game late. But if there’s early traffic, the Cardinals may be forced into a quicker bullpen game than they’d like on the road.
St. Louis Cardinals vs Los Angeles Angels Best Bet
Under 8.5 (+100) (3 out of 5 units)
The number is asking for a fairly normal scoring environment, but the recent profile for both clubs leans toward lower totals, and Detmers’ strikeout ability gives the Angels a cleaner route to six-plus innings without constant ball-in-play volatility. With Dobbins, the goal isn’t perfection—just avoiding the crooked inning that turns this into a slug-by-the-fifth type of game.
Predicted Score
Our computer projections model for this matchup predicts a final score of St. Louis Cardinals 3, Los Angeles Angels 4.