The Week 5 of the NFL will kick off with a TNF game in Denver when the AFC rivals meet on Thursday, October 6, and here you can check out the best Colts vs. Broncos betting pick and odds.

Denver is looking to get the third home win of the campaign when they host Indianapolis at Empower Field at Mile High. The Broncos are 3-point favorites on BetUS Sportsbook, while the total is set at 42.5 points. These AFC rivals will meet for the first time since 2019.

Colts failed to get a comeback win against the Titans

The Indianapolis Colts (1-2-1) couldn’t complete a comeback and secure a win against the divisional rivals Tennessee Titans at home despite keeping the visitors off the scoreboard in the second half. Indianapolis trailed by 14 points at halftime but scored just seven in the second, which wasn’t enough to avoid a 24-17 loss. The Colts totaled more yards (365-243), but committed three turnovers, while the Titans were without one on the other end.

Matt Ryan completed 27 of 37 passes for 356 yards, two touchdowns, and one interception. Mo Alie-Cox caught both Ryan’s TD passes and finished with 85 yards on six receptions, while Alec Pierce added 80 yards on four catches. The Colts couldn’t move the chains on the ground as they had only 38 yards on 23 carries. On defense, Zaire Franklin impressed with game-high 15 total tackles.

LB Shaquille Leonard (concussion) and DE Tyquan Lewis (concussion) are unavailable to play in Denver. RB Jonathan Taylor (ankle) and S Julian Blackmon (ankle) are questionable to feature on Thursday.

Broncos’ defense couldn’t hold off the Raiders in a loss

The Denver Broncos (2-2) suffered their second road defeat of the season as they lost 32-23 to the divisional foes Las Vegas Raiders. The Broncos’ defense, which was rock-solid in the first three weeks, allowed 385 yards and 25 first downs, while the offense collected only 299 yards and 12 first downs.

Russell Wilson played well as he completed 17 of 25 passes for 237 yards, two touchdowns, and no interceptions. He also scored a rushing TD and led the team with 29 yards. Each of KJ Hamler, Jerry Jeudy, and Courtland Sutton, recorded 50+ receiving yards, while Jeudy and Sutton found the end zone. Javonte Williams suffered a season-ending knee injury, and Denver’s run offense didn’t work. Defensively, Josey Jewell and Jonas Griffith combined for 24 tackles.

Denver acquired RB Latavius Murray out of New Orleans’ practice squad to serve as Melvin Gordon’s backup now when Javonte Williams is done for the year. LB Randy Gregory (knee) and Justin Simmons (quadriceps) are on IR. G Billy Turner (knee), S P.J. Locke III (concussion), WR Tyrie Cleveland (hamstring), and S Caden Sterns (hip) are questionable to play on Thursday against Indianapolis.



•            1-5 ATS in the last six games overall

•            1-5 ATS in the last six vs. AFC rivals


•            7-3 ATS in the last ten games after allowing more than 30 points in their previous game

•            17-8 ATS in the last 25 games after allowing more than 150 yards rushing in their previous game

•            14-3 ATS in the last 17 games after accumulating less than 90 yards rushing in their previous game

Indianapolis Colts vs. Denver Broncos Pick  

Melvin Gordon will carry a load now when he’s a clear No.1 running back, but I still think the Broncos will utilize pass offense more because Russell Wilson is starting to develop chemistry with receivers. Indianapolis has one of the best run defenses in the league, which is another reason for the hosts to pass the ball. Denver’s defense is one of the best in the NFL, particularly at home, where they somehow usually managed to edge the opponents. The Colts prefer passing over running with Matt Ryan under the center, but given how good Denver’s secondary is, I don’t think the visitors will be successful in that department on Thursday.

Pick: Take the Broncos at -2.5 (-130)

The Total

We’re dealing with two of the three least efficient offenses in the league, so I don’t expect to see a shootout here. Indianapolis is averaging only 14.3 ppg, while Denver is not much better with 16.5 ppg. The Broncos’ defense is stronger and it allows 17.0 ppg, and I would be genuinely surprised if the rivals combine for more than 40 points. Under is 9-0 in the Colts’ last nine games overall; Under is 5-0 in Indianapolis’ previous five road games, while Under is 8-0 in the Colts’ last eight vs. AFC opponents.

Pick: Go Under 42.5 points (-110)