Game 4 of the 2021 ALDS at Guaranteed Rate Field in Chicago was rained out and rescheduled for Tuesday, October 12, with the first pitch at 2:07 PM ET, so we bring you the best Astros vs. White Sox betting pick and odds.  

Houston is one win away from the American League Championship Series. According to Bookmaker Sportsbook, Houston is a slight +100 road dog for Tuesday’s clash, while the totals are listed at 8.5 runs.

The Astros bring their top ace to the mound              

The Houston Astros easily outlasted the ChiSox in the first two games of the 2021 ALDS, 6-1 and 9-4, playing as slight home favorites. Lance McCullers, who’ll get the starting call in Game 4, tossed 6.2 scoreless innings in the opener while dominating Chicago’s lineup for the second time in 2021.

Back on June 20, Lance took a win in an 8-2 thrashing of the White Sox at Minute Maid Park in Houston, Texas. He threw six frames of a two-hit, two-run ball to improve to 4-1 in six career starts against the ChiSox. The 28-year-old right-hander is 2-1 with a sparkly 2.25 ERA and 0.85 WHIP in three career starts at Guaranteed Rate Field.

McCullers went 13-5 with a 3.16 ERA and 1.22 WHIP in 28 starts (162.1 innings) this past regular season. The Astros bullpen had a disappointing 4.06 ERA and 4.21 FIP, and through the first three postseason games, it has compiled a 5.84 ERA, 1.86 WHIP, and a .327 batting average against.

The White Sox hope for another strong offensive display

With their backs against the wall, the Chicago White Sox smashed the Astros 12-6 as -117 home favorites in Game 3 this past Sunday. They had 16 hits and five walks (24 total bases), while Yasmani Grandal and Leury Garcia went yard each.

On the pitching side of things, the White Sox have struggled mightily so far this postseason. Back on Sunday, Dylan Cease got the nod and gave up three earned runs across 1.2 frames. Michael Kopech also yielded three earned runs while getting seven outs, but Aaron Bummer, Ryan Tepera, Craig Kimbrel, and Liam Hendricks all shut down the Astros.

The White Sox bullpen has registered a 5.28 ERA, 1.17 WHIP, and a .254 batting average against through the first three meetings with the Astros this postseason. Carlos Rodon will get the starting call Tuesday, and he was 2-0 in a couple of starts against Houston last regular season. He’s tossed 14 innings in those two encounters and has fanned 18 while giving up only one earned run on four hits and three walks.

Rodon went 13-5 with a 2.37 ERA and 0.96 WHIP in 24 starts this past regular season. The 28-year-old southpaw has recorded a 1.93 ERA and 2.49 FIP over his last six outings (28 innings pitched).



  • 1-5 in the last six road games against the White Sox 


  • 5-1 in the last six games at home 

Houston Astros vs. Chicago White Sox Pick

The Astros 7-3 against the White Sox in 2021, including their seven-game regular-season series. On the other hand, the ChiSox have lost only one of their previous six home encounters with the Astros. We should see a hard-fought battle in this one that could easily go either way, as both teams will bring guns to the mound.

I’ve mentioned Lance McCullers’ dominance in Game 1 and how good he’s been against the White Sox throughout his career. It’s the same story with Carlos Rodon, who’s allowed a .194/.222/.314 batting line to the current Astros in 103 at-bats against him. I’m going with the White Sox only because they are playing in front of the home fans, though I don’t trust the Astros bullpen either.

Pick: Take Chicago White Sox at -120      

The Total:

Through the first three games of the series, the Astros have slashed .265/.348/.408, while the ChiSox have recorded a .312/.377/.385 batting line. Chicago has smacked eight hits more than Houston (34-26), while both teams have found a way to score runs against each other.

The over is 7-4 in the last 11 meetings between these two foes. Their bullpens cannot be trusted, but if both Lance McCullers and Carlos Rodon continue with a strong performance, this clash will go in the under.

Pick: Go under 8.5 runs at -110